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A 50-year-old man presents with fever, night sweats, and weight loss. A biopsy o

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Question: A 50-year-old man presents with fever, night sweats, and weight loss. A biopsy of a lymph node reveals granulomas. Which infectious agent is most likely responsible?

Options:

  1. Histoplasma capsulatum
  2. Mycobacterium tuberculosis
  3. Coccidioides immitis
  4. Brucella spp.

Correct Answer: Mycobacterium tuberculosis

Solution: 

Granulomas in the lymph nodes are characteristic of tuberculosis, which is caused by Mycobacterium tuberculosis.

A 50-year-old man presents with fever, night sweats, and weight loss. A biopsy o

Practice Questions

Q1
A 50-year-old man presents with fever, night sweats, and weight loss. A biopsy of a lymph node reveals granulomas. Which infectious agent is most likely responsible?
  1. Histoplasma capsulatum
  2. Mycobacterium tuberculosis
  3. Coccidioides immitis
  4. Brucella spp.

Questions & Step-by-Step Solutions

A 50-year-old man presents with fever, night sweats, and weight loss. A biopsy of a lymph node reveals granulomas. Which infectious agent is most likely responsible?
Correct Answer: Mycobacterium tuberculosis
  • Step 1: A 50-year-old man has symptoms: fever, night sweats, and weight loss.
  • Step 2: These symptoms can indicate an infection or illness.
  • Step 3: A biopsy of a lymph node is done to investigate further.
  • Step 4: The biopsy shows granulomas, which are small clusters of immune cells.
  • Step 5: Granulomas are often associated with certain infections, particularly tuberculosis.
  • Step 6: Tuberculosis is caused by the bacterium Mycobacterium tuberculosis.
  • Step 7: Therefore, the most likely infectious agent responsible for the man's condition is Mycobacterium tuberculosis.
  • Granulomatous Inflammation – Granulomas are a type of chronic inflammatory response often associated with infections like tuberculosis.
  • Tuberculosis Presentation – Common symptoms of tuberculosis include fever, night sweats, and weight loss, particularly in adults.
  • Lymph Node Biopsy – A biopsy revealing granulomas can indicate specific infectious agents, with tuberculosis being a primary consideration.
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