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What is the effect of protein binding on drug distribution?

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Question: What is the effect of protein binding on drug distribution?

Options:

  1. Increases free drug concentration
  2. Decreases free drug concentration
  3. Has no effect on drug distribution
  4. Increases drug metabolism

Correct Answer: Decreases free drug concentration

Solution: 

Protein binding decreases the free drug concentration available for distribution, as only unbound drugs can exert pharmacological effects.

What is the effect of protein binding on drug distribution?

Practice Questions

Q1
What is the effect of protein binding on drug distribution?
  1. Increases free drug concentration
  2. Decreases free drug concentration
  3. Has no effect on drug distribution
  4. Increases drug metabolism

Questions & Step-by-Step Solutions

What is the effect of protein binding on drug distribution?
  • Step 1: Understand that drugs can bind to proteins in the blood.
  • Step 2: Know that when a drug binds to a protein, it becomes inactive and cannot work.
  • Step 3: Realize that only the unbound (free) drug can move to where it is needed in the body.
  • Step 4: Recognize that if more drug is bound to proteins, less free drug is available.
  • Step 5: Conclude that higher protein binding means less drug can reach its target and have an effect.
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