Question: What is the effect of alcohol on the metabolism of acetaminophen?

Options:

1. Increases its metabolism to non-toxic metabolites
2. Decreases its metabolism, increasing toxicity
3. Increases its metabolism to toxic metabolites
4. Has no effect on its metabolism

Correct Answer: Increases its metabolism to toxic metabolites

Solution:

Chronic alcohol consumption induces CYP2E1, which increases the metabolism of acetaminophen to toxic metabolites, raising the risk of liver damage.