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What is the mechanism of interaction between statins and grapefruit juice?

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Question: What is the mechanism of interaction between statins and grapefruit juice?

Options:

  1. Inhibition of statin absorption
  2. Inhibition of CYP3A4 metabolism
  3. Induction of statin metabolism
  4. Inhibition of LDL receptor activity

Correct Answer: Inhibition of CYP3A4 metabolism

Solution: 

Grapefruit juice inhibits CYP3A4, which is responsible for the metabolism of many statins, leading to increased statin levels and risk of side effects.

What is the mechanism of interaction between statins and grapefruit juice?

Practice Questions

Q1
What is the mechanism of interaction between statins and grapefruit juice?
  1. Inhibition of statin absorption
  2. Inhibition of CYP3A4 metabolism
  3. Induction of statin metabolism
  4. Inhibition of LDL receptor activity

Questions & Step-by-Step Solutions

What is the mechanism of interaction between statins and grapefruit juice?
  • Step 1: Understand that statins are medications used to lower cholesterol levels in the blood.
  • Step 2: Learn that statins are processed (metabolized) in the body by an enzyme called CYP3A4.
  • Step 3: Know that grapefruit juice contains compounds that can block or inhibit the activity of the CYP3A4 enzyme.
  • Step 4: When CYP3A4 is inhibited by grapefruit juice, it cannot effectively break down statins.
  • Step 5: As a result, more statin remains in the body, leading to higher levels of the medication.
  • Step 6: Higher levels of statins can increase the risk of side effects, which can be harmful.
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