What is the effect of uncouplers on oxidative phosphorylation?

What is the effect of uncouplers on oxidative phosphorylation?

Step 1: Understand that oxidative phosphorylation is a process in cells that produces ATP, the energy currency of the cell.
Step 2: Know that this process relies on a proton gradient, which is a difference in proton concentration across a membrane.
Step 3: Learn that uncouplers are substances that can disrupt this proton gradient.
Step 4: When uncouplers disrupt the proton gradient, protons can flow back across the membrane without generating ATP.
Step 5: Instead of producing ATP, the energy from the proton flow is released as heat.
Step 6: This means that uncouplers lead to increased heat production and decreased ATP production.

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