Step 11: Perform the multiplication: 15 * 4 = 60, then 60 * 81 = 4860.
Step 12: The coefficient of x^2 in the expansion of (2x + 3)^6 is 4860.
Binomial Expansion – The question tests the understanding of the binomial theorem, specifically how to find specific coefficients in the expansion of a binomial expression.
Combinatorics – The use of binomial coefficients (nCr) to determine the number of ways to choose terms from the expansion.
Exponentiation – Understanding how to correctly apply powers to the terms in the binomial expression.