Isomerism and Stereochemistry

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This section focuses on Isomerism and Stereochemistry, one of the most conceptually important areas of Organic Chemistry. It explains how compounds with the same molecular formula can differ in structure or spatial arrangement, leading to significant differences in physical, chemical, and biological properties.

Designed for Class 11–12 students, NEET/JEE aspirants, and undergraduate learners, this category emphasizes conceptual clarity, visualization skills, and exam-oriented problem solving.

In this section, you will study:

• Structural isomerism (chain, position, functional, metamerism, tautomerism)
• Stereoisomerism and its classification
• Geometrical isomerism (cis–trans, E–Z notation)
• Optical isomerism and chirality
• Asymmetric carbon and chiral centers
• Enantiomers and diastereomers
• R–S configuration and Cahn–Ingold–Prelog priority rules
• Racemic mixtures and resolution
• Conformational analysis (ethane, butane, cyclohexane)
• Importance of stereochemistry in biological systems and pharmaceuticals

The content is structured to develop strong spatial understanding and analytical skills, helping students confidently solve mechanism-based and application-oriented questions.

Mastering Isomerism and Stereochemistry builds a solid foundation for advanced Organic Chemistry and plays a crucial role in competitive examinations as well as higher studies in chemistry and life sciences.

Q. What is the IUPAC name for the compound with the structure CH3-CH=CH-CH2-CH3?
  • A. 1-pentene
  • B. 2-pentene
  • C. 3-pentene
  • D. butene
Q. What is the stereochemical configuration of (2R,3S)-2,3-butanediol?
  • A. R,R
  • B. S,S
  • C. R,S
  • D. S,R
Q. What type of isomerism is exhibited by 1-bromobutane and 2-bromobutane?
  • A. Structural isomerism
  • B. Geometric isomerism
  • C. Optical isomerism
  • D. Conformational isomerism
Q. Which of the following compounds can exhibit optical isomerism?
  • A. 2-butanol
  • B. 1-butanol
  • C. butane
  • D. propene
Q. Which of the following compounds is a chiral molecule?
  • A. 2-pentene
  • B. 3-pentanol
  • C. 1-butanol
  • D. 2-butanol
Q. Which of the following compounds is a geometric isomer of 2-butene?
  • A. cis-2-butene
  • B. trans-2-butene
  • C. 1-butene
  • D. butyne
Q. Which of the following is a characteristic of cis isomers?
  • A. Higher boiling points than trans isomers
  • B. Lower boiling points than trans isomers
  • C. Same boiling points as trans isomers
  • D. Always optically active
Q. Which of the following is an example of enantiomers?
  • A. D-glucose and L-glucose
  • B. cis-2-butene and trans-2-butene
  • C. 1-butanol and 2-butanol
  • D. acetone and propan-2-one
Q. Which of the following statements about stereoisomers is true?
  • A. They have the same molecular formula.
  • B. They have different connectivity of atoms.
  • C. They cannot be interconverted without breaking bonds.
  • D. They have different physical properties.
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