Q. In chronic inflammation, which cell type is predominantly found in the tissue?
A.
Neutrophils
B.
Macrophages
C.
Mast cells
D.
Basophils
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Solution
Macrophages are the predominant cell type in chronic inflammation, contributing to tissue repair and the immune response.
Correct Answer:
B
— Macrophages
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Q. In which type of hypersensitivity reaction is the immune response primarily mediated by IgE antibodies?
A.
Type I
B.
Type II
C.
Type III
D.
Type IV
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Solution
Type I hypersensitivity reactions are mediated by IgE antibodies, leading to allergic responses.
Correct Answer:
A
— Type I
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Q. What histological feature is commonly associated with high-grade tumors?
A.
Well-differentiated cells
B.
Increased mitotic activity
C.
Presence of necrosis
D.
All of the above
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Solution
High-grade tumors typically exhibit increased mitotic activity, presence of necrosis, and poorly differentiated cells, making 'All of the above' the correct answer.
Correct Answer:
D
— All of the above
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Q. What is rigor mortis primarily caused by?
A.
Depletion of ATP
B.
Bacterial activity
C.
Dehydration of tissues
D.
Increased body temperature
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Solution
Rigor mortis occurs due to the depletion of ATP, which is necessary for muscle relaxation.
Correct Answer:
A
— Depletion of ATP
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Q. What is the effect of alcohol on the metabolism of acetaminophen?
A.
Increases its metabolism to non-toxic metabolites
B.
Decreases its metabolism, increasing toxicity
C.
Increases its metabolism to toxic metabolites
D.
Has no effect on its metabolism
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Solution
Chronic alcohol consumption induces CYP2E1, which increases the metabolism of acetaminophen to toxic metabolites, raising the risk of liver damage.
Correct Answer:
C
— Increases its metabolism to toxic metabolites
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Q. What is the effect of St. John's Wort on the metabolism of certain drugs?
A.
Inhibits CYP450 enzymes
B.
Induces CYP450 enzymes
C.
Has no effect on drug metabolism
D.
Inhibits P-glycoprotein
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Solution
St. John's Wort is known to induce CYP450 enzymes, which can lead to decreased effectiveness of drugs metabolized by these enzymes.
Correct Answer:
B
— Induces CYP450 enzymes
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Q. What is the hallmark histopathological feature of granulomatous inflammation?
A.
Neutrophilic infiltration
B.
Caseous necrosis
C.
Lymphocytic infiltration
D.
Epithelioid cell formation
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Solution
Epithelioid cell formation is a characteristic feature of granulomatous inflammation, often seen in conditions like tuberculosis.
Correct Answer:
D
— Epithelioid cell formation
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Q. What is the main laboratory method used to identify Mycobacterium tuberculosis?
A.
Gram stain
B.
Acid-fast bacilli stain
C.
Culture on blood agar
D.
PCR
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Solution
The acid-fast bacilli stain is used to identify Mycobacterium tuberculosis due to its unique cell wall properties.
Correct Answer:
B
— Acid-fast bacilli stain
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Q. What is the mechanism of interaction between statins and grapefruit juice?
A.
Inhibition of statin absorption
B.
Inhibition of CYP3A4 metabolism
C.
Induction of statin metabolism
D.
Inhibition of LDL receptor activity
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Solution
Grapefruit juice inhibits CYP3A4, which is responsible for the metabolism of many statins, leading to increased statin levels and risk of side effects.
Correct Answer:
B
— Inhibition of CYP3A4 metabolism
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Q. What is the most common laboratory method used to identify Mycobacterium tuberculosis?
A.
Gram stain
B.
Acid-fast bacilli stain
C.
Culture on blood agar
D.
PCR amplification
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Solution
The acid-fast bacilli stain is the most common laboratory method used to identify Mycobacterium tuberculosis due to its unique cell wall properties.
Correct Answer:
B
— Acid-fast bacilli stain
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Q. What is the most common type of lung cancer associated with smoking?
A.
Adenocarcinoma
B.
Squamous cell carcinoma
C.
Small cell carcinoma
D.
Large cell carcinoma
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Solution
Squamous cell carcinoma is the most common lung cancer type associated with smoking.
Correct Answer:
B
— Squamous cell carcinoma
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Q. What is the most common type of lung cancer?
A.
Small cell lung cancer
B.
Non-small cell lung cancer
C.
Mesothelioma
D.
Lung carcinoid tumor
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Solution
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for approximately 85% of cases.
Correct Answer:
B
— Non-small cell lung cancer
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Q. What is the primary cause of apoptosis?
A.
Cellular stress
B.
Infection
C.
Tissue injury
D.
Programmed cell death
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Solution
Apoptosis is a form of programmed cell death that occurs in a regulated manner, distinct from necrosis.
Correct Answer:
D
— Programmed cell death
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Q. What is the primary cause of livor mortis?
A.
Gravity
B.
Bacterial action
C.
Dehydration
D.
Temperature changes
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Solution
Livor mortis is primarily caused by gravity, which causes blood to settle in the lowest parts of the body.
Correct Answer:
A
— Gravity
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Q. What is the primary cell type found in nervous tissue?
A.
Neurons
B.
Adipocytes
C.
Chondrocytes
D.
Osteocytes
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Solution
Neurons are the primary cell type in nervous tissue, responsible for transmitting signals throughout the body.
Correct Answer:
A
— Neurons
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Q. What is the primary cell type involved in the acute inflammatory response?
A.
Neutrophils
B.
Macrophages
C.
Lymphocytes
D.
Eosinophils
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Solution
Neutrophils are the first responders to sites of acute inflammation, playing a crucial role in the initial immune response.
Correct Answer:
A
— Neutrophils
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Q. What is the primary characteristic used to classify tumors as benign or malignant?
A.
Size of the tumor
B.
Histological appearance
C.
Location of the tumor
D.
Patient's age
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Solution
Tumors are primarily classified as benign or malignant based on their histological appearance, which reflects their cellular characteristics and behavior.
Correct Answer:
B
— Histological appearance
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Q. What is the primary concern when combining MAO inhibitors with tyramine-rich foods?
A.
Hypoglycemia
B.
Hypertensive crisis
C.
Serotonin syndrome
D.
Cardiac arrhythmias
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Solution
Combining MAO inhibitors with tyramine-rich foods can lead to a hypertensive crisis due to excessive norepinephrine release.
Correct Answer:
B
— Hypertensive crisis
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Q. What is the primary function of ciliated columnar epithelium found in the respiratory tract?
A.
Absorption
B.
Secretion
C.
Protection
D.
Movement of mucus
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Solution
Ciliated columnar epithelium helps in moving mucus and trapped particles out of the respiratory tract, aiding in protection and clearance.
Correct Answer:
D
— Movement of mucus
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Q. What is the primary histological feature of atherosclerosis?
A.
Fibrosis
B.
Lipid accumulation
C.
Calcification
D.
Inflammation
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Solution
Lipid accumulation within the arterial wall is a primary histological feature of atherosclerosis.
Correct Answer:
B
— Lipid accumulation
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Q. What is the primary mechanism by which Staphylococcus aureus causes disease?
A.
Production of exotoxins
B.
Invasion of host cells
C.
Formation of biofilms
D.
Induction of apoptosis
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Solution
Staphylococcus aureus produces various exotoxins that contribute to its pathogenicity, including enterotoxins and toxic shock syndrome toxin.
Correct Answer:
A
— Production of exotoxins
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Q. What is the primary mechanism by which Staphylococcus aureus evades the host immune response?
A.
Production of exotoxins
B.
Formation of biofilms
C.
Capsule formation
D.
Endotoxin release
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Solution
Staphylococcus aureus produces a polysaccharide capsule that inhibits phagocytosis, allowing it to evade the host immune response.
Correct Answer:
C
— Capsule formation
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Q. What is the primary mechanism of action for warfarin?
A.
Inhibition of vitamin K epoxide reductase
B.
Inhibition of thromboxane A2 synthesis
C.
Activation of antithrombin III
D.
Inhibition of platelet aggregation
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Solution
Warfarin primarily works by inhibiting vitamin K epoxide reductase, which is essential for the synthesis of vitamin K-dependent clotting factors.
Correct Answer:
A
— Inhibition of vitamin K epoxide reductase
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Q. What is the primary mechanism of cell injury in ischemia?
A.
Oxidative stress
B.
Reperfusion injury
C.
ATP depletion
D.
Inflammation
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Solution
Ischemia primarily leads to ATP depletion due to reduced blood flow, which impairs cellular functions and can lead to cell death.
Correct Answer:
C
— ATP depletion
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Q. What is the primary mechanism of tissue repair following injury?
A.
Apoptosis
B.
Regeneration
C.
Fibrosis
D.
Necrosis
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Solution
Fibrosis is the primary mechanism of tissue repair, involving the deposition of collagen and extracellular matrix components.
Correct Answer:
C
— Fibrosis
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Q. What is the primary method used for the histopathological diagnosis of tumors?
A.
Immunohistochemistry
B.
Flow cytometry
C.
PCR (Polymerase chain reaction)
D.
Ultrasound imaging
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Solution
Immunohistochemistry is the primary method used for the histopathological diagnosis of tumors, allowing for the identification of specific antigens in tissue sections.
Correct Answer:
A
— Immunohistochemistry
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Q. What is the primary mode of transmission for Helicobacter pylori?
A.
Airborne droplets
B.
Fecal-oral route
C.
Vector-borne
D.
Direct contact
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Solution
Helicobacter pylori is primarily transmitted via the fecal-oral route, leading to gastrointestinal infections.
Correct Answer:
B
— Fecal-oral route
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Q. What is the primary mode of transmission for most viruses?
A.
Direct contact
B.
Airborne droplets
C.
Vector-borne
D.
Fecal-oral route
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Solution
Most viruses are primarily transmitted through airborne droplets, especially respiratory viruses.
Correct Answer:
B
— Airborne droplets
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Q. What is the primary mode of transmission for Neisseria gonorrhoeae?
A.
Airborne droplets
B.
Fecal-oral route
C.
Sexual contact
D.
Vector-borne transmission
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Solution
Neisseria gonorrhoeae is primarily transmitted through sexual contact, leading to gonorrhea.
Correct Answer:
C
— Sexual contact
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Q. What is the primary postmortem change that occurs within the first few hours after death?
A.
Rigor mortis
B.
Livor mortis
C.
Algor mortis
D.
Decomposition
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Solution
Algor mortis refers to the cooling of the body after death, which begins within a few hours.
Correct Answer:
C
— Algor mortis
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